Abstract
The presentation will focus-on how Chris Toumazou’s work on sensors and sensor interface technology has been an important step towards closed loop local intelligence for precision medicine. By combining wearable technology with social sciences and nudging behaviour he will show how medical device tech becomes a real time actionable point of decision technology for both implantable as well as truly personalised nutrition and skin health
Biography
Professor Chris Toumazou is Regius Professor of Engineering, Chair in Biomedical Circuit Design, Director of the Centre for Bio-Inspired Technology and Founder and Chief Scientist for the Institute of Biomedical Engineering at Imperial College London. He is also the co-founder & CEO of ground-breaking consumer genetics services provider DnaNudge, and co-founder and Executive Chairman of DNA Electronics, developer of pioneering point-of-need solutions for rapid DNA sequencing. He is honoured with the European Patent Office European Inventor Award, The Royal Society Gabor Medal, the IET Faraday Medal, and Laureate of the UNESCO-Equatorial Guinea International Prize for Research in the Life Sciences – the first ever UK winner. In 2020, Professor Toumazou received the President's Special Award for Pandemic Service from the Royal Academy of Engineering. He is a recipient of the IEEE Field Medal in Biomedical Engineering for Outstanding Contributions to Biomedical Circuit Technology, the Royal Academy of Engineering’s Silver Medal for pioneering contributions to British industry, and the IET’s JJ Thompson Medal for Electronics. In 2013, he was elected Fellow of the Academy of Medical Sciences – adding to his Fellowship of the Royal Academy of Engineering and the Royal Society, and becoming only one of very few people who are Fellows of all three UK national academies. In 2021, Professor Toumazou was elected to International Member of the National Academy of Engineering (NAE) in the US, which is among the highest global professional distinctions accorded to an engineer.
Abstract
Several of brain diseases remain unknown or ununderstood, some of these known diseases can’t be solved by regular clinical treatment. Consequently, wearable and implantable medical devices such as microsystems based closed-loop neuromodulators offer potential solutions. Built around neuromorphic brain-machine interfaces, these devices allow to diagnosis, treat, and predict some of these neurodegenerative diseases. This talk covers end-to-end brain-microsystem interfaces dealing with multidimensional design and implementation challenges such as massively parallel neurorecording sites, various biosensing methods, energy harvesting, power management, very low-power circuits, high-data rate transceivers, small silicon area, large memory room, artificial intelligence algorithms intended for various biomarkers detection, electrical/optical stimulations, etc. Case studies include neurotransmitters detection, neural cells and organoids culture and manipulation, On set detection/prediction of epileptic seizures and Alzheimer, addictions suppression, and vision enhancement.
Biography
Mohamad Sawan is Chair Professor in Westlake University, Hangzhou, China, and Emeritus Professor in Polytechnique Montreal, Canada. He is the founder and director of the Center of Excellence in Biomedical Research on Advances-on-Chips Neurotechnologies (CenBRAIN Neurotech) in Westlake University, and of the Polystim Neurotech Lab in Polytechnique Montreal. He received his Ph.D. degree from the University of Sherbrooke, Canada. He served as a Distinguished Lecturer of both IEEE CASS and IEEE SSCS for three consecutive years each. Co-Founder, Associate Editor and was Editor-in-Chief of the IEEE Transactions on Biomedical Circuits and Systems (2016-2019). He was awarded the Canada Research Chair in Smart Medical Devices (2001-2015) and was leading the Microsystems Strategic Alliance of Quebec (ReSMiQ), Canada (1999-2018). Dr. Sawan received several awards, among them the Barbara Turnbull Award from the Canadian Institutes of Health Research (CIHR), the J.A. Bombardier and Jacques-Rousseau Awards from the Canadian ACFAS, the Queen Elizabeth II Golden Jubilee Medal, the Medal of Merit from the President of Lebanon, the Chinese National Friendship Award, and the Shanghai International Collaboration Award. Dr. Sawan is a Fellow of the Royal Society of Sciences of Canada (FRSC), a Fellow of the Canadian Academy of Engineering (FCAE), a Fellow of the Engineering Institutes of Canada (FEIC), a Life Fellow of the IEEE (LFIEEE), and an “Officer” of the National Order of Quebec.
Abstract
Intracranial BCI can assist severely disabled persons in assistive communication and active rehabilitation. Nevertheless, sustainable BCI implants require minimal invasiveness. We developed a miniaturized epidual BCI implant with only 8 electrodes (NEO system). The 25mm-diameter device can be fitted in the skull, with no battery included. Power was supplied remotely through inductive antenna, and the epidual ECoG were transmitted wirelessly to the receiver attached outside the scalp. The NEO system was tested on white pigs, showing its capacity of stable long-term recording of epidual ECoG, while keeping cortical cells intact. With ensured minimal invasiveness and long-term safety, the first-in-human trial of clinical implantation was made on October 24th, 2023, and the second on December 19th, 2023 respectively. The first tetraplegia patient with spinal cord injury regained the ability of grasping objects, and even drinking water with help of the BCI. Additionally, the patient showed substantial neurological recovery through consecutive BCI upper limb training, regaining the ability to hold objects without BCI assistance. The patient demonstrated a 5-point improvement in ISNCSCI upper limb motor scores and a 27-point increase in the Action Research Arm Test (ARAT). Improvements in electrophysiological assessments point to a considerable recovery in impaired neural circuits. The second BCI-implant patient can control a computer cursor to play games and maneuver a wheelchair just by motor imagery. Both patients have been using the NEO BCI at their home for over 8 months.
Biography
Dr. Bo Hong received his Ph.D. degree of Biomedical Engineering from Tsinghua University in 2001. From 2004 to 2005, he was a visiting scientist in the Department of Biomedical Engineering and the Center for Neural Engineering at Johns Hopkins University, USA. He is now full professor with School of Biomedical Engineering, Tsinghua University, and an investigator of McGovern Institute for Brain Research at Tsinghua. His main research interests are brain computer interface and language network in human brain. His team designed and developed minimally invasive BCI - NEO system and conducted the first-in-human clinical trial successfully in 2023. He has co-authored more than 80 papers on Nature Neuroscience, PNAS, Nature Communications, NeuroImage, Journal of Neuroscience etc. He has served as the Associate Editor of IEEE Transactions on Biomedical Engineering and IEEE Transactions on Neural Systems and Rehabilitation Engineering.